Canada. In October 2008, Dr. Qyang became a principal investigator at the Yale Cardiovascular Research Center and Section of Cardiology, Dept. These groundbreaking achievements have made us one of the leading laboratories in investigation of metabolic syndrome.

Subhash K. Das, Ph.D., graduated fromUniversity of Alberta, Edmonton.

of Internal Medicine, and Yale Stem Cell Center. As a committed clinician and educator, Dr Velazquez has had an active practice in advanced heart failure where he has also trained dozens of fellows who are emerging leaders in this field. Please update your browser or switch to Chrome, Firefox or Safari. Yale Cardiovascular Research Center (YCVRC), https://support.microsoft.com/en-us/help/17621/internet-explorer-downloads, Analytical, Diagnostic and Therapeutic Techniques and Equipment, Single Photon Emission Computed Tomography Computed Tomography. Subsequent molecular and physiological studies in human mutation carriers and animal models have allowed us to unravel novel functions of the identified genes, to delineate their cognate pathways and to discover new targets for pharmaceutical intervention. He was on the faculty at Harvard Medical School, Scripps Research Institute and the University of Virginia prior to moving to Yale in 2011. in developmental biology with Pr. Robert I. Please update your browser or switch to Chrome, Firefox or Safari.

Zhengxin Jiang, Ph.D. (graduated from Baylor College of Medicine, USA), postdoc training in Qyang lab (2013-2015), now is theDirector, Research & Development at Pregene Biotechnolgy.11.

13. The YCVRC genetics program seeks to understand genetic basis of a number of cardiovascular illnesses including early onset coronary artery disease, metabolic syndrome, sudden cardiac death and atrial fibrillation. Colleen A. Lopez, Ph.D., Postdoc Fellows, graduated fromUniversity of Oxford in May 2019 and joined the labin April 2019. In partnership with the Patient Revolution, Erica Spatz, MD, MHS, facilitates peer-to-peer sessions for women to think, feel, and talk about their cardiovascular health. YCVRC houses over 110 investigators (undergraduate and graduate students, postdoctoral trainees and faculty members) interested in basic and translational research. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (, A case of hypoplastic posterior mitral leafletrelated severe mitral regurgitation associated with ostium secundum atrial septal defect, Optimal antiplatelet therapy in patients at high bleeding risk undergoing complex percutaneous coronary intervention, A focus on congenital heart disease and neonatal cardiac regeneration: an exciting future, Resounding victory in golf of the Continental Europe Team of Cardiology, Vicksburg, Jackson, Meridian, Mississippi, https://academic.oup.com/journals/pages/about_us/legal/notices, Receive exclusive offers and updates from Oxford Academic, Transplant Infectious Disease Physician Faculty Positions, Infectious Diseases Translational Investigator, Copyright 2022 European Society of Cardiology. See the results of one of our recent studies in Circulation: Cardiovascular Quality and Outcomes, See the specifics of on our active programs which identifies patients with social needs (housing; food; utilities; transportation), at the point of care, and connects them with a community health worker from PA-NH. He has published over 270 research papers and reviews and has been elected to a number of honorary societies including Association of American Physicians, American Society of Clinical Investigations and Association of University Cardiologists. In addition, YCVRC investigators have full access to the Yale Translational Imaging Center (Y-TRIC) facilities that include a dedicated hybrid CT-SPECT scanner, 2D/3D mouse and large animal echo and other imaging resources. Yale Cardiovascular Research Center (YCVRC), https://support.microsoft.com/en-us/help/17621/internet-explorer-downloads, Analytical, Diagnostic and Therapeutic Techniques and Equipment, Single Photon Emission Computed Tomography Computed Tomography. Yan Huang, Ph.D.,Associate Research Scientist, graduated from Hunan Medical University in China in 1998, and joined the lab 7/1/2018. Dr. Ren was awarded a Connecticut Stem Cell grant ($200,000; 11/1/2012 10/30/2014). It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only.

Dr. Ge was awarded a Brown-Coxe postdoctoral fellowship ($50,000; 7/1/2011 6/31/2012). Phone: (203) 785-4119 Fax: (203) 785-6954 Email: Search for other works by this author on: Senior Vice President, Operations Executive Director, Heart and Vascular Center and Transplantation Center Clinical Service Coordinator, Medicine Associate Clinical Professor, YSM Cardiovascular Medicine. 12. Chris has won an NIH F31 predoctoral fellowship (9/1/2018-8/31/2021). The ability to manipulate these signaling events is critical to development of new classes of therapeutic agents that can promote process such as arteriogenesis or lymphangiogenesis, increase contractility of the failing heart or reverse myocardial hypertrophy. Esra Cagavi Bozkulak, Ph.D. (graduated from University of California, Los Angeles, USA), postdoc training in Qyang lab (2010-2012), now Associate Professor inIstanbul Medipol University, Regenerative and Restorative Medical Research Center, Department of Medical Biology, School of Medicine, Istanbul, Turkey.3. With his Duke colleagues and over 100 centres worldwide, Velazquez led the Surgical Treatment of Ischaemic Heart Failure Trial (STICH). The Center has its own zebrafish facility as well as an extensive array of core facilities. An Eastern Caribbean Health Outcomes Research Network Study team in Trinidad and Tobago. Understanding how smooth muscle cells dramatically alter their phenotype may provide new insights for treatment and prevention of cardiovascular disease. The program is designed to provide a personalized, low-burden, high-touch approach to blood pressure control. Martin Schwartz earned a BA in chemistry from New College in Sarasota FL and a PhD in physical chemistry from Stanford, where he worked in Harden McConnells lab on biophysics of phospholipid membranes.He then did postdoctoral research in biology at MIT in the laboratory of Richard Hynes where he studied interactions of fibronectin with cells and other proteins. Starting in the 1980s, his lab was among the first to report that integrin mediated adhesion could regulate signaling pathways in cells;that integrin-mediated adhesion promotes cell survival, that integrins synergize with growth factor receptors to activate growth signaling pathways and that integrins regulate Rho family GTPases. Dr. Nicolas Baeyens reflects on lessons learned while working with Dr. Martin Schwartz. 7. Jiesi Luo, Ph.D. (Postdoc), graduated from Michigan State University, USA in 2014. Oscar Bartulos-Encinas, Ph.D. (now a Senior Scientist in Ncardia, The Netherlands), graduated from University of Madrid, Spain, in 2009. 5. She has held multiple leadership positions with the American Heart Association, has served as an NIH charter study section member, and currently serves as a co-director of the Yale Cardiovascular Research Center.Dr. She earned her PhD from Case Western Reserve University in Physiology and Biophysics, then completed postdoctoral fellowships in cell biology at Harvard Medical School.

The Section of Cardiovascular Medicine at the Yale University School of Medicine conducts a wide range of clinical research activities at the frontiers of cardiovascular medicine. Levy Professor of Medicine (Cardiology) and Professor of Immunobiology; Associate Chief, Cardiovascular Medicine, Internal Medicine, Associate Professor; Director of Translational Research, Yale Pulmonary Vascular Disease Program, Internal Medicine; Co-Director of the Vascular Research T32 Training Program, Internal Medicine; Leadership Committee, 3CPR Council, Ensign Professor of Medicine (Cardiology) and Professor of Cellular And Molecular Physiology; Co-Director, Yale Cardiovascular Research Center (YCVRC), Associate Professor of Medicine (Cardiology); Co-Director, Yale Cardiovascular Research Center (YCVRC), Professor of Medicine (Cardiology) and of Genetics; Director, Cardiovascular Genetics Program; Director, Cardiovascular Module, Professor of Medicine (Cardiovascular Medicine) and Pharmacology; Co-Director, Yale Cardiovascular Research Center (YCVRC), Professor; Director of the Zebrafish Phenotyping Core for Precision Medicine, Internal Medicine and Genetics; Co-Director, Yale Cardiovascular Research Center (YCVRC), Associate Professor of Medicine (Cardiology) and of Pathology; Section of Cardiovascular Medicine, Robert W. Berliner Professor of Medicine (Cardiology) and Professor of Biomedical Engineering and of Cell Biology, Associate Professor of Medicine; Director of Heart Failure Research, Cardiovascular Medicine; Co-Director Heart & Vascular Center Clinical Research, Heart & Vascular Center, Professor of Medicine (Cardiology) and of Cellular And Molecular Physiology. She is a Professor of Medicine and a practicing clinical cardiologist at Yale New Haven Hospital and the director of the Yale Heart and Vascular Clinical Research Program. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. Luke Batty, M.S., graduated from University of California, Los Angeles, in 2017, and joined the lab as a Yale graduate student since4/1/2018. The primary approach of my current research program is prospective mechanistic human studies in hospitalized heart failure patients, for which we have established extensive infrastructure. Email: keith.churchwell@yale.edu; Keith.Churchwell@YNHH.ORG, Gary V Desir, MD, Keith B Churchwell, MD, New chief of cardiovascular medicine at Yale School of Medicine, European Heart Journal, Volume 39, Issue 19, 14 May 2018, Page 1665, https://doi.org/10.1093/eurheartj/ehy197. Dr. van Dijkcompleted his PhD in Computer Science at the University of Amsterdam and the Weizmann Institute of Science,where he used machine learning to understand how gene regulation is encoded in DNA sequence. Zelun Wang, undergraduate summer student 2013 from Rice University, now a MD/PhD student in Washington University Saint Louis.25. Alone 7 former lab members have joined academia over the past 5 years and 11 a pursuing a career in research as trainees. Most recently, we have established techniques of high throughput gene editing and multiple parallel reporter assays in my laboratory and have successfully mapped the regulatory landscape of a number of GWAS disease genes. 9.

Xin Ge, Ph.D., (graduated from University of Minnesota, Twin Cities, USA), postdoc training in Qyang lab (2010-2013). He next joined Dr. Kenneth R. Chien's laboratory at the University of California, San Diego and then the Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School and Harvard Stem Cell Institute. PCHY offers a state-of-the-art program to manage hypertension. Your browser is antiquated and no longer supported on this website. Carol Suh, graduate student who obtained a M.S. Oxford University Press is a department of the University of Oxford. Dr. Simons has an extensive track record of NIH funding including multiple R01s and he has served as a Principal Investigator of the NHLBI SCOR program in endothelial biology. Clinical research and device development experience includes First-in-Man, regulatory CE Mark and IDE/IND phase II and III trials, and post market and investigator-initiated clinical programs. Peter John Amos, Ph.D., (graduated from University of Virginia), postdoc training in Qyang lab (2010-2013), nowan officer for Patents and Innovations in Life Sciences inSeattle. My research laboratory studies the role of endothelial cells, the cells that line blood vessels, in solid organ transplant rejection. In this endeavor, we have developed novel, patient-centered protocols heavily incorporating human biospecimens to increase the likelihood that findings derived from these assays will be clinically relevant. In addition to Yale-New Haven Hospital, research enrollment and follow-up is conducted at numerous affiliated hospitals and clinics, including: For a list of current cardiovascular & heart clinical trials please visit.

Dr. Amos was awarded a Connecticut Stem Cell grant ($200,000; 9/1/2011 6/30/2013) during his training in Qyang lab. Karen Xiao, Summer Intern 2012, undergraduate student at Georgetown University.24.

He has served as Chief of the Cardiovascular Imaging Section and Director of the Duke Cardiac Diagnostic Unit and Echocardiography Laboratories since 2007. Vascular and lymphatic development: A. Eichmann, S-W Jin, M. Simons, S. Nicoli He led the first trials of therapeutic angiogenesis in the USA and his basic research discoveries have played an important role in moving the field forward.

Jinkyu Park, Ph.D. (Postdoc), graduated from Seoul National University, South Korea in 2013. Kathleen Martin, PhD, graduated from Hiram College, where she majored in Biology. 18. He is now a physician at Guangdong General Hospital. Mehran M. Sadeghi, MD, studied medicine at Necker Enfants Malades School of Medicine and earned his medical degree from the University of Paris in 1991. Genetics, genomics & pharmacogenomics: J. Hwa, A. Mani, W. McKenna (UCL), The goal of stem cell biology investigations at YCVRC is to develop a through understanding of processes involved in cell differentiation with the view towards developments of stem cell-based regenerative therapies for cardiac and neurological diseases. Dr. Akar's laboratoryis dedicated to uncovering the mechanisms that promote arrhythmias in common structural heart diseases and to develop novel gene-based approaches to prevent these malignant arrhythmias. This interaction extends even further with the vasculature playing an important role in modulating nervous system plasticity during development and in adult tissues. He completed his internal medicine and cardiology training at Duke University, including Fellowships in clinical research and echocardiography. In 1993 he joined faculty at Harvard Medical School as an Assistant Professor of Medicine and rose through the ranks to become an Associate Professor of Medicine, Director of the Morse Coronary Care Unit and Director of Angiogenesis Research Center. Luke has won theYale University Gruber Science Fellowship in2017 andan NIH F31 predoctoral fellowship (9/1/2019-8/31/2022).Previous Qyang lab members:1. Please update your browser or switch to Chrome, Firefox or Safari. of Computer Science where he leads a research group that focuses on the cutting-edge application of machine learning methods to big biomedical data. Prior to establishing the Cardiovascular Molecular Imaging Laboratory, Dr. Sadeghi completed his residency and fellowship training at Yale New Haven Hospital followed by a postdoctoral fellowship at the Boyer Center for Molecular Medicine.The goal of the Cardiovascular Molecular Imaging Laboratory is to develop novel in vivo imaging approaches to visualize, characterize and quantify molecular and cellular processes involved in the development of cardiovascular diseases, and to address novel aspects of vascular and valvular biology.

studies on glial cell development with Bernard ZALC at INSERM, Salptrire Dr Velazquez is currently Professor of Medicine in the Division of Cardiology at Duke University and holds appointments at the Duke Clinical Research Institute and Duke Global Health Institute. After receiving his Ph.D. degree, he spent the next year conducting postdoctoral research at Baylor College of Medicine, where he studied myeloproliferative diseases with a mouse model of presenilin deficiency. He completed a postdoctoral fellowships in molecular cardiology at National Heart Lung and Blood Institute in Bethesda and in vascular biology at MIT. He was named Professor of Medicine with Tenure in 2012. Our work involves population and family-based genetic studies, high throughput sequencing to identify disease genes, with a focus on coronary artery disease (CAD) and metabolic syndrome (MetS). Xiangyu Shi, M.D., Ph.D. candidate fromXiangya School of Medicine, Central South University, China, joined the lab 7/1/2018-8/31/2020. Attendees participate in activities that help them consider important decisions such as diet exercise. All rights reserved. Published on behalf of the European Society of Cardiology. PCHY supports research in basic and translational science, clinical trials, digital health and real world data studies, along with epidemiology and population health. Dr. Hwa was then awarded a Howard Hughes Physician Postdoctoral Fellowship to continue studies at M.I.T in the laboratory of Nobel Laureate, H. Gobind Khorana. Studies at the Y-TRIC focus on multi-modality imaging, molecular imaging and cardiovascular device development. These investigations are being carried out in close collaborations with Department of Neurology, Yale Stem Cell Center and UCL. Muhammad Riaz, Ph.D., Associate Research Scientist, graduated from Erasmus University Medical-Center, Rotterdam, the Netherlands in 2012, and joined the lab 1/1/2017. Strikingly, knockdown of Dyrk1b is protective against these traits, motivating further investigations to characterize the protein as an attractive therapeutic target.

His current research program combines studies using biophysical, cellular and animal approaches to important questions about integrin signaling, mechanotransduction and disease in the vascular system. We work with trainees at all levels to develop skills and forge new scientific discovery related to genetics, imaging, risk-reductive medications and lifestyle interventions, remote patient monitoring, digital therapeutics, clinical and patient-reported outcomes and health disparities. Yale Cardiovascular Research Center (YCVRC), https://support.microsoft.com/en-us/help/17621/internet-explorer-downloads, Confocal microscopy:point scanning (Leica) and spinning disk (Perkin Elmer) microscopes equipped for fixed and live cell imaging, Primary cell isolation and mouse genotyping (Arteriogenesis PPG core), Mouse physiology: in vivo and ex vivo studies of cardiac function, Langerhans hearts, blood pressure and ECG monitoring, Micro-CT core: in vitro and in vivo micro-CT imaging, Mouse breeding core: management of mouse colonies, Surgical and imaging core: large animal surgery and imaging (Arteriogenesis PPG core), Zebrafish facility: includes zebrafish housing as well facilities for live fish imaging and microinjections. At the same time, we are exploring the utility of iPS-derived defined cell types from patients with complex illnesses for molecular diagnostics. Large vessel development: D. GreifHemogenic endothelium: K. Hirschi, The vascular and the nervous system are the first two systems to develop and they share a remarkable number of features including the overall network architecture and many signaling molecules and receptors. Yongming Ren, Ph.D. (now a Senior Scientist at Vita Therapeutics, USA), graduated from Tsinghua University, China, in 2007. Alexandra Lansky, MD, FESC, FACC, FAHA, FSCAI, is the Director of the Yale Cardiovascular Research Group. Mengyan Liu, undergraduate summer student 2014 from University of New Haven.27. In 2014, he was elected to the American Society of Clinical Investigation.