Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS). doi: 10.1016/0960-0760(95)00106-A, 33. In the context of SARS virus infection, supercomputer SUMMIT drug-docking screen and gene set enrichment analyses (GSEA) finds that quercetin, VD, and estradiol interferes the functioning of 85, 70 and 61% of the SARS-CoV-2 viral proteins in human cells, respectively. 2003 Feb;22(1):18-35. Review. (2020) 8:186. doi: 10.3389/fpubh.2020.00186, 89. doi: 10.1016/j.fct.2015.05.022, 53. Available online at: https://nutritiondata.self.com/foods-002101119000000000000-1w.html (accessed May 27, 2020). (2015) 7:193344. They rigorously source and test all raw materials and undertake in-depth research to ensure the best herb-active constituents and clinically relevant applications. Rev Med Virol. N Engl J Med. Studies also indicate the involvement of oxidative stress in the pathogenesis of COVID-19. doi: 10.1111/jgs.14679, 38. Sforcin JM. Their supplements offer a means to health and vitality, with formulas that draw on the latest scientific evidence, as well as centuries of traditional knowledge. (2017) 30:36674. intended to diagnose, treat, cure, or prevent disease. Cell. Selenium supplementation suppresses pathogen induced activation of NF-B and its downstream pro-inflammatory cytokine release (79). Hunt C, Chakravorty NK, Annan G, Habibzadeh N, Schorah CJ. See below the Top 10 Immune-Boosting Herbs and Supplements: Vitamin C (or its chemical form L-ascorbic acid) is known for its potent antioxidant and antiviral effects. doi: 10.21203/rs.3.rs-31855/v1, 11. Int Immunopharmacol. Liu MJ, Bao S, Napolitano JR, Burris DL, Yu L, Tridandapani S, et al. doi: 10.4049/jimmunol.0803217, 34. Zinc supplementation for the prevention of acute lower respiratory infection in children in developing countries: meta-analysis and meta-regression of randomized trials. Vitamin D modulation of innate immune responses to respiratory viral infections. Carr AC, Maggini S. Vitamin C and immune function. Standard Process sells through health care professionals. I have a Zinc Taste Test in the office I will perform on you for free. Behera MK, Shukla SK, Dixit VK, Nath P, Abhilash VB, Asati PK, et al. (2004) 78:113349. Many foods like red onion, berries, elderberry, and green tea contain this important antioxidant. Ajoene, a compound of garlic, induces apoptosis in human promyeloleukemic cells, accompanied by generation of reactive oxygen species and activation of nuclear factor kappaB. (2017) 28:137492. It inhibits inducible NO nitric oxide synthase expression in activated macrophages (66, 67). Int J Mol Sci. Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, Levine M. Vitamin C as an antioxidant: evaluation of its role indisease prevention. Zinc is an important mineral and nutrient that is required for many processes in the body. The S protein has two domains S1 and S2. There are numerous other ways to help strengthen and expediate an immune response that we can cater to the individual. The virus enters the airway epithelium after binding its S protein to the ACE2 receptors and subsequent priming by the cellular transmembrane protease, serine 2 (TMPRSS2). doi: 10.1371/journal.ppat.1001176, 26. SUNDAY: CLOSED, Wholistic Health Services of Vermont | Sitemap | Accessibility | Website by DOCTOR Multimedia. Liao, L. Y., He, Y. F., Li, L., Meng, H., Dong, Y. M., Yi, F., & Xiao, P. G. (2018). As an antioxidant, it scavenges ROS, prevents lipid peroxidation, and protein alkylation and thus protects cells from oxidative stress induced cellular damage (46). They are also devoid of animal-based ingredients such as dairy, eggs, honey, beeswax, and lanolin. Roth DE, Richard SA, Black RE. Several shreds of evidence indicate that many nutritional supplements from various spices, herbs, fruits, roots, and vegetables can reduce the risk or severity of a wide range of viral infections by boosting the immune response, particularly among people with inadequate dietary sources and also by their anti-inflammatory, free radical scavenging, and viricidal functions. Standard Process products labeled as Non-Dairy or Non-Dairy Formula have been formulated to not contain milk or milk-derived ingredients. Keep out of reach of children.
doi: 10.1016/S2213-2600(20)30076-X, 18.
These results indicate that piperine possesses a direct antioxidant effect against various free radicals (76). Though there are no reports that VD directly affects the virus replication or viral load, studies reveal that VD could contribute to antiviral activity through suppression of virus-induced inflammation. FRIDAY: CLOSED The virus binds to a type of receptor molecule found in the nasal epithelium called intracellular adhesion molecule-1 (ICAM-1). Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry. In vitro antioxidant activity of piperine. (1995) 125:1704S8. This correlates with increased activity of HAS2 and the subsequent lung pathology induced by the SARS-CoV-2 infection. Therefore, exploring the repurposing of natural compounds may provide alternatives against COVID-19. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Br J Dis Chest.
Monlezun DJ, Bittner EA, Christopher KB, Camargo CA, Quraishi SA. (2000) 22:2714. If theyre not favorites of yours already, this is a great place to start. doi: 10.1164/ajrccm/139.3.682, 19. It exerts its antioxidant effects both by neutralizing free radicals and enhancing the production of antioxidant enzymes (5760). Together, with immunomodulatory and antiviral effects, propolis can be tried as a prophylactic support against COVID-19. (2005) 28:171721. Viruses. Recently, scientists have found supplementing with Quercetin may have anti-viral effects. Supplements straight to your patients' door, [Checklist] 6 Foods That Support Your Immune System, Why A 3-Day Detox Doesn't Actually Detoxify Your Body, Microbiome Support & Nutritional Supplements, Help maintain and support healthy immune system function, regulation and response, Help promote the bodys normal resistance function, Encourage the bodys normal healthy defense system by supporting healthy immune system function*. Zinc regulates the acute phase response and serum amyloid a production in response to sepsis through JAKSTAT3 signaling. Clinical characteristics of coronavirus disease 2019 in China. Following its entry, the virus inhibits or delays the host innate interferon (IFN) immune response. DO NOT send personal health information through this form.
The clinical effects of vitamin C supplementation in elderly hospitalised patients with acute respiratory infections. In fact, several in-vitro experiments found Quercetin could inhibit the entry of certain viruses by blocking the receptors on cells to which the viruses enter, and possibly preventing certain infections. Though mechanism of their immunomodulating and anti-inflammatory effects in the lung are not clearly understood. Research has found supplementing with certain minerals, vitamins and herbs may be beneficial in supporting our immune system and promoting longevity. Quercetin has long been revered for its antioxidant potential. Several studies have found that consuming Vitamin C may activate an immune response against certain flu viruses.
Mashhadi, N. S., Ghiasvand, R., Askari, G., Hariri, M., Darvishi, L., & Mofid, M. R. (2013). COVID-19 infection: the perspectives on immune responses. Molecules (Basel, Switzerland),23(10), 2475. https://doi.org/10.3390/molecules23102475, 4. Figure 1. (2015) 4:188. doi: 10.4103/1735-5362.192488, 100.
Grouping some of these phytonutrients in the right combination in the form of a food supplement may help to boost the immune system, prevent virus spread, preclude the disease progression to severe stage, and further suppress the hyper inflammation providing both prophylactic and therapeutic support against COVID-19. For example, thyme fresh (267%RDA), turmeric (43%RDA), cardamom (35%RDA), coriander (35%RDA), beetroot juice are good sources of VC (45). 10. Here we find what to fix, and fix what we find. 
Ionic zinc also has an affinity to the ICAM-1 receptor due to its electrical charge. doi: 10.1002/14651858.CD013292, 44. (24) demonstrated that Zn exposure (100 M) was shown to reduce recombinant human ACE-2 activity in rat lungs. 49. It exerts antiviral effect by various mechanisms ranging from inhibiting the virus entry into cells, inhibiting encapsulation of the virus and viral protease, inhibiting the virus replication, as well as modulating several signaling pathways (54). All authors: contributed to the article and approved the submitted version. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Because of its substantial role in suppressing the inflammation and augmentation of antioxidant status and innate immunity, selenium supplementation may be useful in fight against COVID-19. Bureau G, Longpr F, Martinoli MG. Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation. Genes Nutr. Ou X, Liu Y, Lei X, Li P, Mi D, Ren L, et al. These herbs provide many phytochemicals including an essential oil (containing monoterpenes and other terpenes), the naphthodianthrones hypericin and pseudohypericin (hypericins), flavonoids, phenolics, triterpenoid saponins (especially glycyrrhizin) and other saponins. The flower itself can also be consumed as a healthful tea. (2018) 148:2006. Standard Process products labeled as Non-Grain or Non-Grain Formula have been formulated to not contain any true cereal grain or grain-derived ingredients such as those from wheat, rice, oats, cornmeal, barley, or another cereal grain. Baicalin is found to strengthen the immune system with its ability to neutralize pathogens. (2013) 2013:751068. doi: 10.1155/2013/751068, 90. Lf inhibits viral entry via binding to cell surface molecules or viral particles or both. (2011) 17:518490. Allicin inhibits spontaneous and TNF-alpha induced secretion of proinflammatory cytokines and chemokines from intestinal epithelial cells. Catanzaro M, Corsini E, Rosini M, Racchi M, Lanni C. Immunomodulators inspired by nature: a review on curcumin and echinacea. doi: 10.1016/j.ejphar.2006.03.002, 65. The recommended dose of VC varied from 1 to 3 g/day. doi: 10.3168/jds.2018-16103. Zn2+ cations especially in combination with Zn ionophore pyrithione were shown to inhibit SARS-coronavirus RNA polymerase (RNA dependent RNA polymerase, RdRp) activity by suppressing its replication (25). Chen Y, Zhang J, Ge X, Du J, Deb DK, Li YC. Respiratory antiviral immunity and immunobiotics: beneficial effects on inflammation-coagulation interaction during influenza virus infection. 6985 Woodstock Rd (Rte 4)Quechee, VT 05059. During the phase 2 of the infection, in addition to maintaining the general health condition of affected patients, the line of treatment may be focused on adapting the strategies including the use of nutritional supplements that can suppress the ongoing oxidative stress, acute-inflammation and cytokine storm so that destruction and damage caused to affected tissues is prevented. COVID-19 infection and oxidative stress: an under-explored approach for prevention and treatment? (2017) 42:448. (2020) 110. World J Gastroenterol WJG. Makela MJ, Puhakka T, Ruuskanen O, Leinonen M, Saikku P, Kimpimaki M, Blomqvist S, Hyypia T, Arstila P. Viruses and bacteria in the etiology of the common cold. Bang JS, Oh DH, Choi HM, Sur BJ, Lim SJ, Kim JY, et al. Also it suppresses H2 O2 -induced oxidative stress in human umbilical vein endothelial cells (99). Furthermore, evidence also suggests that VD can supplement the effectiveness of drug treatment as observed in the case of ribavirin therapy for treatment-nave patients with chronic Hepatitis C virus (HCV) genotype 1 and HCV genotype 2e3 infections (33, 34, 38, 39). The virus interferes with downstream signaling by ubiquitination and degradation of RNA sensor adaptor molecules such as mitochondrial antiviral-signaling (MAVS) protein and tumor necrosis factor receptor-associated factors (TRAF) 3/6 and inhibiting interferon regulatory factor (IRF) 3 nuclear translocation (8). Older people are most often deficient in these important micronutrients. Zinc modulates cytokine-induced lung epithelial cell barrier permeability. Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. reduced systemic inflammatory response syndrome and other infections (92). Front Immunol. J Immunol Baltim Md 1950. Inhibition of lipopolysaccharide-induced inflammatory responses by piperine. Similarly, there are several drug candidates that have been identified and most are in various stages of research and development, whilst some of them have been repurposed and approved for emergency use in this pandemic. Org Lett. Channappanavar R, Perlman S. Pathogenic human coronavirus infections: causes and consequences of cytokine storm and immunopathology. Further, it also modulates nuclear factor of activated T cells (NFAT) and NF B signaling pathways (82, 83). To keep your immune system in top working order there are a number of things you can do. 2022 Standard Process Inc. All rights reserved. The onset of clinical disease and its progression to the severe stage may vary between individuals and that depend upon their immune status, and the presence of underlying medical conditions. Ginde AA, Blatchford P, Breese K, Zarrabi L, Linnebur SA, Wallace JI, et al. J Pharmacol Pharmacother. Antiviral Mechanism of Action of Epigallocatechin-3-O-gallate and Its Fatty Acid Esters. Thus far, the infection has spread to almost all countries globally and was declared a pandemic by the WHO. probiotics for the treatment of infantile colic: a systematic review. Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. Quercetin & Rutin (Quercetin-3-O-rutinoside) are a naturally occurring polyphenol and flavonoid, best known for its potent anti-inflammatory and immune-enhancing abilities. In vivo studies performed on mice showed oral administration of Baicalin was effective in inhibiting the proliferation of certain viruses, demonstrating the antiviral activity of Baicalin. We are thankful to the Director and to CSIR-CFTRI for providing facilities to carry out this study. VD a fat-soluble vitamin, plays a vital role in both in immunomodulatory, antioxidant and antiviral responses (29, 30). There is a list of herbs that have been cited in herbal medical literature for their immune-boosting abilities. 108. The immune system is composed of a group of chemicals, cells, proteins and tissues that work together to destroy anything it perceives as a threat to our well-being. (2015). PLoS ONE. www.standardprocess.com/Products/Standard-Process/Immuplex#.Xm-t4Ep7m00, www.standardprocess.com/Products/MediHerb/Echinacea-Premium#.Xm-u7Ep7m00, www.standardprocess.com/Products/MediHerb/Astragalus-Complex#.Xm-s6kp7m01, www.standardprocess.com/Products/MediHerb/Viranon#.Xm-cY0p7m00, www.standardprocess.com/Products/Standard-Process/Congaplex#.Xm-waEp7m00. Allicin suppresses the inflammation via inhibiting the TNF- induced expression levels of IL-1, IL-8, IP-10, and IFN- and also through suppression of degradation of NF-B inhibitory protein IB in intestinal epithelial cells (65). Ting D, Dong N, Fang L, Lu J, Bi J, Xiao S, et al. This article outline 10 anti-viral herbs and supplements that are known for their immune-enhancing properties. The details of the pathogenesis of SARS-CoV-2 infection is not clearly understood. It regulates inflammatory activity and has antiviral and antioxidant functions (19).
Biol Pharm Bull. 45. The plethora of existing literature provides the scientific evidence on immune-boosting, anti-inflammatory, antioxidant, and antiviral properties of several phytonutrients as summarized in Table 1. Green Tea can be enjoyed as a tea or taken as a dietary supplement for an extra health boost. (1989) 139:6827. Therefore, the use of natural compounds may provide alternative prophylactic and therapeutic support along with the therapy for COVID-19. Management of individuals in phase 1, along with mounting specific adaptive immune response, and use of antivirals is critical to prevent the virus entry, replication as well as the disease progression to phase 2. Zahedipour F, Hosseini SA, Sathyapalan T, Majeed M, Jamialahmadi T, Al-Rasadi K, et al. Echinacea root has been used traditionally to: Help enhance healthy immune system function*, Help relieve temporary mild throat discomfort associated with hoarseness, dry throat and irritants*, Contrary to what some say, you can take this every day and even year-round. 2. This product contains two herbs with standardized levels of key phytochemicals to ensure optimal strength and quality. Zinc should also be considered part of your immune regimen. (1999) 6:136. Semin Immunopathol. doi: 10.1016/S0944-7113(99)80029-4, 71. It was fast-tracked for use as a corona vaccine, but experts have expressed concern about the vaccine's efficacy and safety since it has not yet been evaluated in phase 3 clinical trials. Currently, several vaccines and drugs are being evaluated for their efficacy, safety, and for determination of doses for COVID-19 and this requires considerable time for their validation. In some cases, I use separate products. Lin CW, Lin KH, Hsieh TH, Shiu SY, Li JY. 5. MediHerb is a leader in herbal supplements among health care professionals and Standard Process is their exclusive U.S. distributor. Wimalawansa SJ. Bell TJ, Brand OJ, Morgan DJ, Salek-Ardakani S, Jagger C, Fujimori T, et al. (2006) 30:184855. These products are not doi: 10.1021/jf903698s, 105. PH and PVR: edited the article. (1998) 53:4027. Int J Epidemiol. Small molecules blocking the entry of severe acute respiratory syndrome coronavirus into host cells. doi: 10.1080/08820139.2018.1496098, 79. Since most soils and foods today do not have much SE it might be a good idea to consider Astragalus. THURSDAY: 8:30 am-5:00 pm (2017) 4:ofx059. Registered clinical trials of food supplements (Source: ClinicalTrials.gov). The coronavirus disease (COVID-19) was first reported in late 2019 from Wuhan's city in China. I recommend this when your body should have a fever or when the fever is persisting. Lee SC, Wang SY, Li CC, Liu CT. Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice. Chu, M., Xu, L., Zhang, M., Chu, Z., & Wang, Y. Read SA, Obeid S, Ahlenstiel C, Ahlenstiel G. The role of zinc in antiviral immunity.
The viral replication, in turn, triggers the activation of monocytes, macrophages, granulocytes resulting in the hyper inflammatory condition described as cytokine storm with the massive secretion of pro-inflammatory cytokines including interleukin (IL)-1, IL-6, IL-8, IL-12, tumor necrosis factor (TNF)-, etc. Astragalus Complex. Standard Process Quality from Seed to Supplement. (2010) 642:15462. bioRxiv. doi: 10.1016/j.arcmed.2020.04.019, 12. Ganesan S, Faris AN, Comstock AT, Wang Q, Nanua S, Hershenson MB, et al. (2019) 8:30. doi: 10.3390/biology8020030, 31. Vitamin D status and acute respiratory infection: cross sectional results from the United States National Health and Nutrition Examination Survey, 2001-2006. Am J Biomed Sci Res. (2020) 181:27180.e8. Further, quercetin metabolite (4',5-diacetyloxy-3,3',7-trimethoxyflavone) has been shown to inhibit the picornavirus replication by inhibiting the RNA replicase complex (107). In India, there were more than 3M positive cases, and more than 57K reported deaths. Standard Process products labeled as Non-Dairy or Non-Dairy Formula have been formulated to not contain milk or milk-derived ingredients. The immunomodulatory role of probiotics in allergy therapy. Repurposing of these nutrients in the right combination to achieve the functional synergy in the form of ready-to-eat food supplements may provide both prophylactic and adjuvant therapy against COVID-19. Cinnamaldehyde is also known to downregulate the production of prostaglandins (PGEs) by downregulating IL-1-induced COX-2 activity thus lowering the chances of hyper inflammation in a dose-dependent manner (64). Planta Med. Impact of vitamin D supplementation on influenza vaccine response and immune functions in deficient elderly persons: a randomized placebo-controlled trial. Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models. Arthritis Res Ther. The predominant thiosulfinate in fresh garlic extract identified as allicin, has shown a number of health benefits due to its anti-inflammatory, antioxidant and antiviral properties. It is mainly used as a nutritional additive in infant formulas and clinical studies, with doses ranging from 100 mg to 4.5 g a day for various indications without apparent toxicities. Various spices, herbs, fruits, and vegetables have found to be excellent sources of VC (44). Vitamins C and E: beneficial effects from a mechanistic perspective. Avoid excessive exposure to UV radiation (e.g. World J Gastroenterol. (2013) 8:e62482.
doi: 10.1093/ije/dyp391, 28. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Sharma G, Im SH. International journal of preventive medicine,4(Suppl 1), S36S42. These herbs have been traditionally used in herbal preparations to: Andrographis, Echinacea angustifoliaroot and Holy Basil provide a unique range of phytochemicals including diterpenoid lactones (collectively referred to as andrographolides), flavonoids, caffeic acid derivatives (especially echinacoside and cynarin), alkylamides, essential oil (rich in monoterpenes and sesquiterpenes, typically eugenol) and polyphenols. Open Forum Infect Dis. Bao S, Knoell DL. Additionally, studies also suggest that SARS-CoV-2 infection triggers the activation of NF-B-toll-like receptor (TLR) signaling pathways to induce the oxidative stress and hyper inflammatory response, ultimately leading to acute lung injury (11). (2007) 595:10525. Barclay LR, Vinqvist MR, Mukai K, Goto H, Hashimoto Y, Tokunaga A, et al. The chart can be found here: Potential Herb-Drug Interactions Chart. Propolis produced by honeybees and known to have a broad spectrum of biological properties, including anti-microbial, anti-inflammatory, dermatoprotective, laxative, anti-diabetic, anti-tumor, and immunomodulatory activity (82). Therefore, it plays a crucial role in preventing the virus entry and replication (97). [10]. If this sounds like you, give me a call, Ill assist you in handling stressnaturally.. To reduce the chance of an infection of any type, your tissues have to be strong and your detox pathways need to be working well.