https://doi.org/10.1097/PAS.0000000000000535. The extent of peritoneal involvement was assessed by using the Peritoneal Cancer Index (PCI) and scored as 30 [17]. doi: 10.1245/s10434-013-2879-8, 15. Concerning patients with histopathological unfavourable features, high cytological grade and mutational status with unknown potential, the possibility of disease manifestation at unusual sites should always be taken into consideration. This may be related to the growth pattern of the tumor cells and ovarian retention. doi: 10.1002/bjs5.97, 14. These findings imply that ovarian preservation is a more suitable option for young females with low-grade PMP compared to high-grade PMP. Int J Clin Oncol. Active surveillance and watchful waiting were discussed, to further monitor the patients condition.
Google Scholar. Carr NJ, Cecil TD, Mohamed F, et al. Post-mortem diagnosis of haemolytic transfusion reaction was excluded by laboratory investigations. This study was approved by the Ethics committee of the Aerospace Center Hospital, Beijing, China (no. On multivariate analysis, high-grade histopathologic subtype of PMP was an independent predictor of poor prognosis (OS and DFS).
Google Scholar. Ann Surg Oncol.
https://doi.org/10.1016/j.clcc.2018.11.007. Sugarbaker PH. 1b). Spontaneous pregnancy following cytoreduction with peritonectomy and hyperthermic intraperitoneal chemotherapy. (2011) 98:28792. Eur J Surg Oncol. On multivariate analysis, high-grade histopathologic subtype of PMP was an independent predictor of poor prognosis (OS and DFS) (Tables2, 3). During follow-up, the patient developed intraperitoneal recurrence together with intraluminal depositions in the ileum, both disease manifestations with identical KRAS and SMAD4 mutations. Median time from diagnosis of PMP to CRS was 1 month. Google Scholar. World Journal of Surgical Oncology In the ovarian preservation group, patients were stratified by histopathologic subtype of PMP (LG-MCP, n=10; HG-MCP, n=9). Davison JM, Hartman DA, Singhi AD, et al.
https://doi.org/10.1002/bjs5.50134. D SMAD4 immunohistochemistry showing loss of SMAD4 expression in the peritoneal disseminated mucinous neoplasm, consistent with the presence of SMAD4 mutation.
Int J Surg. (*: p<0.05). Early recurrence after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Increased awareness of unusual dissemination patterns may help other clinicians to interpret similar findings, select optimal diagnostic modalities and determine further treatment and prognosis. Tan GHC, Chia CS, Tan SH, Soo KC, Teo MCC. Further prospective studies should be done investigating the role of resection of uninvolved ovaries in PMP. 2013;20(13):422430. These areas can be technically difficult to ensure complete debulking [10, 15, 16]. Pleura and Peritoneum. Previous studies showed higher rates of ovarian invasion in patients with grade 23 PMP (25); specifically, 62% of ovaries were invaded in patients with grade-1 PMP, and 87.5% of ovaries were invaded in patients with grade 23 PMP (26). Following cytoreduction, hyperthermic intraperitoneal chemotherapy was applied using the open Coliseum technique with Mitomycin C for 90 min at 42C, according to the standardized Dutch CRS-HIPEC protocol [18]. Consent for participation in this study was provided by the patients relatives. Sugarbaker PH. BMC Surg. Early and long-term outcome data on 2298 patients with pseudomyxoma peritonei of appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Mittal R, Chandramohan A, Moran B. Pseudomyxoma peritonei: natural history and treatment. https://doi.org/10.1016/j.jss.2012.12.040. Figure 2. Both mutations were also present in the intraperitoneal localizations of high-grade PMP. The patients provided written informed consent to participate in this study. 2008;45(8):52775. van Eden WJ, Kok NFM, Snaebjornsson P, et al. Consequently, we recommend ovarian resection during CRS in patients with HG-MCP. After the procedure, all patients conceived and gave birth to healthy babies. Early- and long-term outcome data of patients with pseudomyxoma peritonei from appendiceal origin treated by a strategy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol. Factors influencing long-term survival after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei originating from appendiceal neoplasms. Hereafter, the patient was referred to our hospital, a tertiary centre, for further treatment. Arch Gynecol Obstet.
2014;27(11):152139. Cisplatin 6080mg or mitomycin (20mg/m2) was warmed to 41C42C and circulated intraperitoneally for 6090min using a closed-abdomen technique. All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Int J Clin Oncol.
doi: 10.1200/JCO.2011.39.7166, 23. Ahmadi N, Kostadinov D, Sakata S, et al. In the ovarian preservation group, patients median age was 37 years (range, 2145 years). Shortly after, the patient was readmitted with clinical symptoms of pyelonephritis, confirmed by positive urinalysis and abdominal CT scan, requiring treatment with oral antibiotics (CD grade 2 complication). Google Scholar. By using this website, you agree to our No patients died within 90 days after CRS in two groups. Narasimhan V, Wilson K, Britto M, Warrier S, Lynch AC, Michael M, et al. Evers DJ, Verwaal VJ. Pleura Peritoneum. (2021) 47(11):294851. A 75-year-old male was referred for unexplained symptoms of nocturia, polyuria, and unintentional weight loss in October 2018. Dissection of the ileum during cytoreduction could induce a risk of tumour cell entrapment within the ileal loop. 1998;55(2):1308. https://doi.org/10.1097/00000658-199402000-00001. Pseudomyxoma peritonei (PMP) is a rare disease characterized by the presence of mucinous ascites produced by peritoneal implants [1, 2]. 1. Cite this article. Enteroscopy via end ileostomy revealed a 5-cm sessile polypoid mass at approximately 60 cm with bleeding tendency, impeding further passage and intubation (Fig. https://doi.org/10.1055/s-2005-916281. Received: 22 February 2022; Accepted: 5 May 2022;Published: 6 June 2022. Median OS and median DFS were not reached (Figures2A,B). J Clin Pathol. Cytoreduction aims to resect all macroscopic disease to reduce intra-abdominal tumour burden, while the subsequent HIPEC eradicates microscopic residual tumour cells [7, 8].
In another study of 42 patients who underwent CRS+HIPEC, 5-year survival rates after first and second CRS were 75.5% and 67.7%, respectively (23).
(2019) 3:195202. Loss of SMAD4 expression is associated with worse overall survival, and these findings might explain the clinically aggressive behaviour in this patient [26]. Oncology. In end-stage disease, adherence of tumour cells to small bowel surfaces is inevitable and can cause bowel obstruction [2]. Assoc Coloproctol G B Irel. With no remaining surgical treatment options for the progression of PMP, nor treatment possibilities for anaemia caused by the bleeding intraluminal lesions, the patient was referred back to the initial teaching hospital and received blood transfusions as part of palliative care. At least one ovary was preserved in 21 women. Appendiceal tumours and pseudomyxoma peritonei: literature review with PSOGI/EURACAN clinical practice guidelines for diagnosis and treatment. Gastroenterol Res Pract. Objective: To determine prognosis for young female patients with peritoneal pseudomyxoma (PMP) of appendiceal origin and unilateral or bilateral ovaries preserved during cytoreductive surgery (CRS). (2012) 30:244956. https://doi.org/10.1186/s12957-022-02613-2, DOI: https://doi.org/10.1186/s12957-022-02613-2.
Eur J Surg Oncol (EJSO). Kaplan-Meier curves showing disease free survival (A) and overall survival (B) of female patients with PMP of appendiceal origin and unilateral or bilateral ovaries preserved during CRS. Mercier F, Dagbert F, Pocard M, Gor D, Quenet F, Wernert R, et al. Disparate findings between the present study and previous findings may be explained by differences in the patient populations. *Correspondence: Ruiqing Ma maruiqing2014@126.com Dongmei Lu 421804323@qq.com, Specialty section: This article was submitted to Surgical Oncology, a section of the journal Frontiers in Surgery, Management of Peritoneal Surface Malignancies. Clavien PA, Barkun J, De Oliveira ML, et al. Seven months after initial surgery, the patient was admitted to the hospital with severe anaemia (haemoglobin of 3.4 mmol/L, MCV of 69fL, ferritin of 7g/L), without signs of hematemesis or objectified melena. https://doi.org/10.3748/wjg.v22.i34.7692. Gong Y, Wang X, Zhu Z. Pseudomyxoma peritonei originating from transverse colon mucinous adenocarcinoma: a case report and literature review. Further large-scale studies are needed to confirm our results. 2c). Tumour markers were increased (CA 19.9 of 760 U/mL, CEA of 28 g/L) and a thoracoabdominal CT scan showed progression of known mucinous depositions in the hepatic and epigastric region. (*: p<0.05). (2018) 20:70410. Jacquet P, Averbach A, Stephens AD, Stuart OA, Chang D, Sugarbaker PH.
3). This is the first reported case of PMP with intraluminal recurrence involving the small bowel. Comparison of disease-free survival (C) and overall survival (D*) based on histopathologic subtype of PMP (low-grade vs. high-grade). Int J Hyperthermia. (2017) 33:5119. No other biochemical deviations were observed in complete blood counts, renal-, or liver function tests. https://doi.org/10.1515/pap-2016-0008. An esophagogastroduodenoscopy excluded gastro-intestinal bleedings. In time, pseudomyxoma polyps can potentially be formed in the wall of the ileum. 19 patients chose ovarian preservation while 21 patients underwent ovarian resection. Among patients with LG-MCP, median OS was 108 months, and the 5-year survival rate was 71.1%. The following case represents an extremely rare location of intraluminal PMP originating from a mucinous appendiceal neoplasm. Most notably, PMP is a rare disease; therefore, small sample size may have affected our findings. (2020) 302:7939.
CCR scores were CCR-0 in all patients. https://doi.org/10.1245/s10434-006-9174-x. Upon outpatient assessment, the patientreported occasional pain in the lower abdomen before flatulency. Hereafter, the patient was treated with palliative care. https://doi.org/10.1245/s10434-019-07879-7. Govaerts K, Lurvink RJ, De Hingh IHJT, et al. Other women have conceived following treatment with CCRS+HIPEC. CCR scores wereCCR-0 in all patients. Review: pathology and its clinical relevance of mucinous appendiceal neoplasms and pseudomyxoma peritonei. Springer Nature. Article doi: 10.1016/j.ejso.2013.03.005, 27. Unusual site of pseudomyxoma peritonei recurrence after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: a case report of intraluminal disease manifestation in the small bowel, https://doi.org/10.1186/s12957-022-02613-2, https://doi.org/10.1067/j.cpsurg.2008.04.003, https://doi.org/10.1097/PAS.0000000000000535, https://doi.org/10.1016/j.ejso.2020.02.012, https://doi.org/10.1245/s10434-012-2229-2, https://doi.org/10.1016/j.jss.2012.12.040, https://doi.org/10.1245/s10434-021-10093-z, https://doi.org/10.1097/00000658-199402000-00001, https://doi.org/10.1245/s10434-006-9174-x, https://doi.org/10.1016/j.suronc.2019.03.004, https://doi.org/10.1007/978-1-4613-1247-5_23, https://doi.org/10.1245/s10434-013-3145-9, https://doi.org/10.1097/01.sla.0000133083.54934.ae, https://doi.org/10.1097/SLA.0b013e3181b13ca2, https://doi.org/10.1038/modpathol.2014.37, https://doi.org/10.1016/j.clcc.2018.11.007, https://doi.org/10.1186/s12893-019-0508-6, https://doi.org/10.1016/j.ejso.2016.01.015, https://doi.org/10.1097/PAS.0000000000000194, https://doi.org/10.1136/jclinpath-2018-205095, https://doi.org/10.1245/s10434-019-07879-7, http://creativecommons.org/licenses/by/4.0/, http://creativecommons.org/publicdomain/zero/1.0/.
Last, the follow-up time was not long enough, especially for patients with preserved ovaries. The ovary is a reproductive and endocrine organ that has a rich blood supply, which may promote tumor growth and metastasis.
In the ovarian preservation group, median overall survival (OS) was 59 months (range, 5365 months), and the 5-year survival rate was 37.9%. Cross-sectional images showing mucinous ascites and tumour infiltration of the mesentery and abdominal wall (A), and an indistinct cecum mass, indicated by the white arrow (B). This clinical entity most commonly originates from ruptured mucinous appendiceal neoplasms, causing the dissemination of tumour cells throughout the peritoneal cavity [3]. Among 963 patients with PMP who were treated at the Aerospace Center Hospital, Beijing between January, 2009 and December, 2019, 888 (92%) patients had PMP of appendiceal origin, including 436 (49%) female patients and 452 (52%) males. Sugarbaker PH. Kyser K, Bidus MA, Rodriguez M, Rose GS, Elkas JC. Elias D, Duchalais E, Dartigues P, Duvillard P, Poirot C, Gor D. A new policy regarding ovarian resection in young women treated for peritoneal carcinomatosis. Cancer Treat Res. 2012;30(20):244956. 10 patients experienced disease progression.
